Ebola-HIV-RNA viruses

This could also be relevant for Ebola, which also is a single-stranded RNA virus:

HIV vaccine

The body’s initial “vaccine-reaction” against HIV could be prolonged if the viruses were inactivated. In comparison, the poliovirus can be inactivated by cleavage of its RNA by ammonia. Hopefully, the same can be true for HIV. Both viruses contain single-stranded RNA and proteases. Maybe the proteases perform (catalyse) aminolysis and cut the RNA strands. HIV has even RNase H which is specialized in breaking RNA strands. The phosphates (PO4-) in RNA repel water more than ammonia, and they are thus favoring aminolysis over hydrolysis. (NH3 is a stronger nucleophile than H2O).

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC354068/?page=1

The tight encapsulation/packing of RNA in the viruses will probably promote the aminolysis process. The hydrophobic cores in the ribonucleoproteins will attract ammonia.

And the host cells use RNases to hydrolyse foreign RNA. Maybe the RNases switch to aminolysis when ammonia is available, and thereby speed up this defense.

In this regard, inhalation of ammonia could be a way to destroy HIV and other RNA viruses in blood and tissue.

http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_10%3A_Phosphoryl_transfer_reactions/Section_10.4%3A_Phosphate_diesters

Written by:

Ottar Stensvold

Molde 
Norway

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About ottarstensvold

Molde Norway
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One Response to Ebola-HIV-RNA viruses

  1. Pingback: Ebola-HIV-RNA viruses | Ottarstensvold's Blog

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